Commonly used medicines for the prevention and treatment of COVID-19

The main preventive measures recommended by WHO against COVID-19 include:

  1. Keeping hands clean: washing them with soap for at least 20 seconds
  2. Wearing a mask in public spaces and closing the nose and mouth when sneezing and coughing
  3. Minimizing contact with people with flu symptoms

In addition to these measures, we can fight the COVID-19 pandemic by using two commonly used medicines to prevent this infection.

The following measures should help to prevent the infection and improve the treatment of infected patients

  1. It is recommended to rinse the oropharynx once a day for 60 seconds using a solution of hydrogen peroxide at a concentration of 0.5-1% (do not swallow), then after 10 minutes rinse with warm water (not recommended for children under 16).

  2. It is recommended to rinse the nasopharynx and rinse the oropharynx with a solution of povidone-iodine, at a concentration of 0.23% for 15 seconds 4 times a day.

Through the use of these two available medicines, the coronavirus can be inactivated in the nasopharynx/oropharynx.

These preventive measures are recommended for healthcare professionals; for healthy individuals who have been in contact with infected and suspected COVID-19; persons with confirmed infection at an early stage of the disease, as well as persons in close contact with patients diagnosed with COVID-19.

These recommendations are not indicated for patients with COVID-19 if they develop lower respiratory tract damage (bronchitis, pneumonia, respiratory failure, ARDS, and others)

Procedure

Preventing Coronavirus Infection

  • Gargle once a day for 60 seconds with hydrogen peroxide, 0.5-1% – do not swallow

To rinse the mouth with hydrogen peroxide in the desired concentration of 0.75% – it is necessary to dilute a 3% solution of hydrogen peroxide in water, in proportions of one to four (3 portions of water and one part of a 3% solution of hydrogen peroxide)

  • Nasal spray 4 times/day and gargle for 15 seconds, Povidone-iodine solution, 0.23% – do not swallow

Hydrogen peroxide: a guide to use, results

hydrogen peroxide

Hydrogen peroxide: This is a mild antiseptic, often used for rinsing, rinsing the mouth, and helps relieve minor mucosal inflammation. On contact with the affected mucous membrane, hydrogen peroxide releases oxygen. The release of oxygen promotes foaming, which helps clear mucus from the affected area.

Hydrogen peroxide can cause the foam to come out of the mouth, which is a normal reaction.

It has been scientifically proven that hydrogen peroxide in concentrations of 0.5% is capable of inactivating viruses similar to human coronaviruses: 229E and SARS CoV; FFM. This has been shown under experimental conditions on hard surfaces when hydrogen peroxide was applied for 60 to 120 seconds.

Several studies have investigated the ability of hydrogen peroxide to retain antigenic epitopes, and other studies have used it as an inactivating agent to develop viral vaccines against DNA and RNA viruses, including lymphocytic choriomeningitis virus (LCMV), yellow fever virus (YFV), West Nile virus (WNV), Vaccinia virus (VV) and monkeypox virus (MPV) rabies virus.

In other words, the virus killed by hydrogen peroxide will act as an antigen to produce specific antibodies.

Typically, hydrogen peroxide is available in pharmacies as a 3% aqueous solution.

To rinse the mouth with hydrogen peroxide in the desired concentration of 0.75%, it is necessary to additionally dilute a 3% solution of hydrogen peroxide in water, in a ratio of one to four (3 portions of water and one part of a 3% solution of hydrogen peroxide).

The diluted solution will contain 0.75% hydrogen peroxide.

Recommendations

  1. Use a solution of hydrogen peroxide at a concentration of 0.5 – 1% (not recommended for children under the age of 16) to rinse the oropharynx once a day, gargle for 60 seconds, do not swallow the solution. After 10 minutes, rinse the oropharynx with warm water.
  2. For those infected early, the use of hydrogen peroxide is recommended, which can be an advantage in reducing viral load by allowing the immune system to prepare.
  3. Most patients with COVID-19 onset have a low or high temperature and flu-like symptoms. Early replication of the virus is more concentrated in the epithelial cells of the oral cavity and nasal cavity. Inflammatory changes in the lungs usually only occur at the beginning of the second week. Reducing viral load early in the infection can prevent pneumonia and allow enough time for an immunological response. This can reduce the severity of the disease.

Povidone-iodine: benefits, instructions for use, and results

Povidone iodine

Povidone-iodine is a broad-spectrum antimicrobial drug that has been used in infection control and prevention for over 60 years.

Povidone-iodine has well-established general antimicrobial activity, demonstrating in vitro efficacy against many bacteria and a wide range of enveloped and non-enveloped viruses, including Ebola and MERS-CoV.

Given its proven in vitro efficacy, povidone-iodine rinsing may be an effective method of preventing the spread of respiratory viruses.

The benefit of rinsing with povidone-iodine solution has been noted in the Japanese clinical practice guidelines for respiratory infections.

Four times a day, a nasal spray, and a 15-second rinse with povidone-iodine solution (do not swallow), 0.23% concentration are enough to kill the coronavirus in the nose and mouth.

This has been documented in published studies.

The safety profile of povidone-iodine is well established. Unlike other antiseptics, povidone-iodine oral products do not irritate or damage the oral mucosa, even with prolonged use.

Although slight systemic absorption of iodine can occur with prolonged use, such clinical manifestations since thyroid dysfunction are not very common in the case of povidone-iodine solution.

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